Abstract
The possible toxic effects of organic polymeric polyphosphonates, which are of potential use in the prophylaxis of dental caries and calculus, have been investigated. Uptake of these polymers from the gut, studied with the use of 32P-labelled materials, is extremely low-less than 2·5 × 10 −5% of the ingested dose. Subacute toxicity tests on rats fed a level of polyethylene polyphosphonate in the diet providing an intake of about 50 mg/kg/day, and acute toxicity tests in mice and rats given a single oral dose of up to 10 g/kg did not provide evidence of any significant detrimental effects. The low toxicity observed is explained by the extremely low absorption of these compounds into the body.
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