Fatal systemic toxoplasmosis in a 3-month-old young tibetan goat (Capra hircus)

Silvia Pavone,Laura Madeo,Deborah Cruciani,Jacopo Zema,Marco Gobbi,Simone Morelli,Silvia Crotti,Nicoletta D’Avino

doi:10.1186/s12917-020-02641-8

Abstract

BackgroundToxoplasmosis is one of the most common parasitic infections in both humans and animals. It is a frequent cause of abortion and stillbirth in intermediate hosts, especially sheep and goats but rarely causes fatal clinical form in adult animals.Case presentationIn contrast, the study reports an unusual fatal case of toxoplasmosis in a young goat naturally infected with type II strain of Toxoplasma gondii. A three-month-old female goat was presented with dyspnea and died few days later. Grossly, lungs were firm, edematous and mottled with disseminated whitish areas. Generalized lymphadenopathy was found. The histopathological examination showed necrotic interstitial bronchopneumonia and necrotizing lymphadenitis with intralesional free and clustered within macrophages tachyzoites of T. gondii. DNA extracted from lungs and lymph nodes was positive for T. gondii by a fast qPCR. PCR-RFLP analysis and sequencing of GRA6 gene showed that the isolated strains belonged to type II genotype.ConclusionsThis is an unusual report of acute systemic toxoplasmosis caused by the type II strain of T. gondii with a fatal outcome in a young goat.

Highlights

Toxoplasmosis is one of the most common parasitic infections in both humans and animals
This is an unusual report of acute systemic toxoplasmosis caused by the type II strain of T. gondii with a fatal outcome in a young goat
Rare cases of systemic fatal toxoplasmosis in adult goats have been reported [3] and recently an outbreak in dairy goats characterized by abortion, stillbirth and death of adult goats occurred in Brazil [4]

Summary

Introduction

Toxoplasmosis is one of the most common parasitic infections in both humans and animals. Conclusions: This is an unusual report of acute systemic toxoplasmosis caused by the type II strain of T. gondii with a fatal outcome in a young goat. Rare cases of systemic fatal toxoplasmosis in adult goats have been reported [3] and recently an outbreak in dairy goats characterized by abortion, stillbirth and death of adult goats occurred in Brazil [4].

Results

Conclusion