Abstract
Paraquat (dipyridylium) is a highly toxic compound with a pungent smell. It is commonly used for weed killing. Intoxication occurs mainly by oral ingestion. After ingestion severe impairment of multiple organs develops. There is no specific antidote. Treatment includes repeated activated charcoal hemoperfusion with pulse methylprednisolone, cyclophosphamide, and antioxidants. Here we report a case of 15-year-old girl who presented with history of attempted suicide with paraquat. Patient died due to respiratory failure despite aggressive treatment and hemodialysis.J Enam Med Col 2017; 7(2): 107-110
Highlights
Paraquat (1,1′-dimethyl-4,4′-dipyridylium) is a broad spectrum quaternary nitrogen liquid herbicide which leads to severe and fatal toxicity after accidental and intentional ingestion.[1]
We report a case of 15-year-old girl who presented with history of attempted suicide with paraquat
It inhibits reduction of NADP to NADPH during photosynthesis. This disruption leads to the formation of superoxide anion, singlet oxygen, and hydroxyl and peroxyl radicals. These reactive oxygen species (ROS) interact with the unsaturated lipids of membranes causing destruction of plant organelles leading to cell death.[2]
Summary
Rukhsana Parvin[1], Md Kamrul Hasan[2], Priyanka Sarkar[3], Nazmun Nahar Mouri[3] Received: November 30, 2016 Accepted: April 30, 2017 doi: http://dx.doi.org/10.3329/jemc.v7i2.32657
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