Fatal multiorgan failure due to yellow fever vaccine-associated viscerotropic disease

Jon L Belsher,Peter Gay,Margo Brinton,Joseph Dellavalla,Robert Ridenour,Robert Lanciotti,Andrey Perelygin,Sherif Zaki,Christopher Paddock,Troy Querec,Tuofu Zhu,Bali Pulendran,Rachel B Eidex,Edward Hayes

doi:10.1016/j.vaccine.2007.08.061

Fatal multiorgan failure due to yellow fever vaccine-associated viscerotropic disease

Jon L Belsher, Peter Gay + Show 12 more

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https://doi.org/10.1016/j.vaccine.2007.08.061

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Journal: Vaccine	Publication Date: Sep 18, 2007
Citations: 81	License type: unspecified-oa

Affiliation: Mayo Clinic, Georgia State University, Robinson Memorial Hospital, Centers for Disease Control and Prevention, Emory and Henry College, University of Washington

#Yellow Fever Vaccine-associated Viscerotropic Disease #Yellow Fever Vaccination + Show 8 more

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Abstract

Yellow fever vaccine-associated viscerotropic disease (YEL-AVD) is a rare complication of yellow fever (YF) vaccination. A previously healthy 22-year-old female died following YF vaccination despite aggressive measures. Serial viral load titers, cytokine levels and host genetic factors were evaluated in an attempt to understand this unusual and lethal outcome. The patient's high-titer vaccine viremia and possibly related minor genetic anomalies provide clues to exploring the etiology of YEL-AVD.

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