Abstract
Abstract Granulibacter bethesdensis is a pathogen reported to cause recurrent lymphadenitis exclusively in persons with chronic granulomatous disease. We report a case of fatal meningitis caused by a highly virulent G. bethesdensis strain in an adolescent in Europe who had chronic granulomatous disease.
Highlights
Granulibacter bethesdensis is a pathogen reported to cause recurrent lymphadenitis exclusively in persons with chronic granulomatous disease
We report animal data comparing this G. bethesdensis strain with the strain recovered from recurrent lymphadenitis in a US Chronic granulomatous disease (CGD) patient
Mayer et al reported an X-linked CGD patient in the United States who died of fulminant infection with an organism with 100% identity to 500 bp of G. bethesdensis 16S [11]
Summary
Granulibacter bethesdensis is a pathogen reported to cause recurrent lymphadenitis exclusively in persons with chronic granulomatous disease. D) Pathology images of gp91 KO mouse lung after CSF strain infection. E) Pathology images of gp91 KO mouse lungs after type strain infection. We used mouse models of CGD to determine whether differences existed in immune response, pathogenicity, or severity of disease between the European (CSF strain) and the US (type strain) strains.
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