Abstract
IntroductionWell-documented cases of untreated cervical intra-epithelial dysplasia resulting in fatal progression of invasive cervical cancer are scarce because of a long pre-invasive state, the availability of cervical cytology screening programs, and the efficacy of the treatment of both pre-invasive and early-stage invasive lesions.Case presentationWe present a well-documented case of a 29-year-old Caucasian woman who was found, through routine conventional cervical cytology screening, to have pathologic Papanicolaou (Pap) grade III D lesions (squamous cell abnormalities). She subsequently died as a result of human papillomavirus type 18-associated cervical cancer after she refused all recommended curative therapeutic procedures over a period of 13 years.ConclusionThis case clearly demonstrates a caveat against the promotion and use of complementary alternative medicine as pseudo-immunologic approaches outside evidence-based medicine paths. It also demonstrates the impact of the individualized demands in diagnosis, treatment and palliative care of patients with advanced cancer express their will to refuse evidence-based treatment recommendations.
Highlights
Well-documented cases of untreated cervical intra-epithelial dysplasia resulting in fatal progression of invasive cervical cancer are scarce because of a long pre-invasive state, the availability of cervical cytology screening programs, and the efficacy of the treatment of both pre-invasive and early-stage invasive lesions.Case presentation: We present a well-documented case of a 29-year-old Caucasian woman who was found, through routine conventional cervical cytology screening, to have pathologic Papanicolaou (Pap) grade III D lesions
We have presented the case of a woman who had a pathologic cervical cytology screening at the age of 29 years, and died as a result of cervical cancer at the age of 42 after she had denied all recommended curative therapeutic procedures for 13 years
In summary, we have presented an unusual case of untreated, presumably human papillomavirus (HPV) type 18-induced cervical dysplasia with progression to invasive and metastatic cervical cancer that demonstrated a ten-year lead time between the diagnosis of dysplasia and invasive cancer
Summary
We have presented an unusual case of untreated, presumably HPV type 18-induced cervical dysplasia with progression to invasive and metastatic cervical cancer that demonstrated a ten-year lead time between the diagnosis of dysplasia and invasive cancer. This case serves as a caveat against the promotion and use of complementary alternative medicine as pseudo-immunologic approaches outside evidence-based medicine paths. 9. Schlecht NF, Platt RW, Duarte-Franco E, Costa MC, Sobrinho JP, Prado JC, Ferenczy A, Rohan TE, Villa LL, Franco EL: Human papillomavirus infection and time to progression and regression of cervical intraepithelial neoplasia. Competing interests The authors declare that they have no competing interests
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