Abstract
We report an immunocompetent patient who had fatal encephalopathy after mild influenza. He rapidly died after unusual symptoms related to intracerebral thrombosis and hemorrhage. A brain biopsy specimen was positive for influenza A(H1N1)pdm09 virus RNA, but a lung biopsy specimen and cerebrospinal spinal fluid samples were negative.
Highlights
Influenza-related neurologic complications are rare, especially in immunocompetent adults
We describe fatal encephalitis in the form of central venous thrombosis associated with influenza A(H1N1)pdm09 virus infection in an immunocompetent man
The incidence of neurologic complications from influenza A(H1N1)pdm09 has not been determined, and it is not clear whether this pandemic was associated with increased neurologic complications compared with those of seasonal influenza [5]
Summary
Influenza-related neurologic complications are rare, especially in immunocompetent adults. Argaud); and Centre National de Référence des Virus Influenza Région Sud France, Lyon A cranial computed tomographic (CT) scan showed thrombosis of the superior sagittal sinus associated with 3 cerebral hematomas (left frontal and bilateral parieto-occipital) and diffuse cerebral edema with signs of increased intracranial pressure (Figure). Results of real-time PCR for CSF were negative for influenza A(H1N1)pdm09 virus, herpes simplex virus (HSV1 and HSV2), and enterovirus.
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