Abstract
Munchhausen’s syndrome (MS) is a chronic factitious disorder characterized by the intentional production of clinical symptoms without external incentive. One type of MS is factitious Cushing syndrome, an extremely rare clinical situation in which the diagnosis is challenging mainly due to interference of the exogenous medication in cortisol immunoassays. We described a 26-year-old woman who was originally diagnosed with a macroprolactinoma and during follow-up developed clinical and laboratorial hypercortisolism. A transsphenoidal surgery was performed and immunohistochemistry revealed positive and diffuse staining for both hormones. Four years later, her hypercortisolism recurred and the confirmation of factitious Cushing syndrome was delayed due to conflicting laboratorial results.
Highlights
Open AccessFatal Factitious Cushing’s Syndrome (Münchhausen’s Syndrome) in a Patient with a Prolactinoma and Silent Corticotrophinoma: Case Report and Literature Review
Factitious Cushing’s syndrome (CS) is extremely rare condition and its diagnosis is challenging mainly due to a cross reactivity of endogenous and exogenous glucocorticoids in immunoassays
We reported a case of factitious CS with a fatal outcome
Summary
Fatal Factitious Cushing’s Syndrome (Münchhausen’s Syndrome) in a Patient with a Prolactinoma and Silent Corticotrophinoma: Case Report and Literature Review. Minanni Ca1*, Cardoso Ala, Albuquerque Eva, Lopes Lml, Glezer A1, Verduguez Eru, Gallucci-neto J2, Gattaz Wf2, Mendonça Bb1, Bronstein Md1, Machado Mc1 and Fragoso Mcbv
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