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Abstract
Myelodysplastic syndrome (MDS) usually presents with cytopenias because of bone marrow failure. Solid organ infarcts in myelodysplastic syndrome (MDS) is rarest complication. We report an elderly male, admitted with complaints of pain abdomen mainly in both flanks and swelling all over the body. Peripheral blood smear, bone marrow aspirate for cytology were suggestive of myelodysplastic syndrome(MDS) with refractory anaemia. Fluorescence in situ hybridization(FISH) were negative for any chromosomal abnormalities. His CECT abdomen was done which revealed hepatosplenomegaly with hyperdense liver with multiple splenic and renal infarcts and patient was treated as a case of MDS with refractory anaemia with solid organ infarcts. Over a period of 3 days, he had Acute Kidney Injury (AKI). Patient succumbed on fifth day.
Highlights
Myelodysplastic syndrome (MDS) refers to “heterogenous group of bone marrow disorders characterized by clonal hematopoiesis, progressive bone marrow failure, and a propensity to transform into acute myeloid leukaemia (AML)”(1,2)
The complications of MDS are related to cytopenia and the progression to Acute myeloid leukaemia[1,2]
We report a case of MDS presenting with bilateral renal, splenic infarction
Summary
Myelodysplastic syndrome (MDS) refers to “heterogenous group of bone marrow disorders characterized by clonal hematopoiesis, progressive bone marrow failure, and a propensity to transform into acute myeloid leukaemia (AML)”(1,2). MDS generally presents with anaemia, often with thrombocytopenia and neutropenia. The complications of MDS are related to cytopenia and the progression to Acute myeloid leukaemia[1,2]. Prognosis of MDS is evaluated by IPSS(International Prognostic Scoring System) score which considers cytogenetics, Bone marrow blasts(percent), haemoglobin, platelets and absolute neutrophil count. Bleeding manifestations in MDS is related to thrombocytopenia and worsened due to platelet dysfunction [3]. Acute thromboembolism, which is leads to occlusion of blood supply and causing organ infarction, is rare in patients with MDS. We report a case of MDS presenting with bilateral renal, splenic infarction
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