Abstract

Background: Obesity is an imbalance between height and weight due to excessive body fat tissue. The purpose of writing this review is to find out the effect of enzyme inhibitor induction on fat-rich foods as control of obesity. Method: Writing and assessing source problems related to using literature study methods. Results: One way of controlling obesity is by regulating dietary patterns and consumption of lipase inhibitors. Inhibition of lipase is one of the most widely developed effective ways in diet medicine. Inhibitory compounds cause pancreatic lipase to lose its ability in decomposition that enters the blood. The potency of plant-origin lipase inhibitor compounds can be increased in both number and performance. Increasing the production of secondary metabolite group inhibitors is by fermentation of microorganisms. Conclusion: Inhibition of triglyceride hydrolysis through inhibition of lipase enzymes can decrease and prevent obesity. Secondary metabolite induction can be fermented with microorganisms. The production of secondary metabolite compounds in medicinal plants can be increased in the presence of fermentation. Flavonoids can decrease the accumulation of lipids in the heart, reduce glucose absorption, inhibit the breakdown of polysaccharides into monosaccharides.

Highlights

  • Obesity is a condition of imbalance between height and weight due to excessive body fat tissue (Listiyana, Mardiana, & Prameswari, 2013)

  • The research procedure carried out in the preparation of this narrative review is to look for various literature studies electronically by accessing national and international article searches and books through databases such as Google Scholar, ScienceDirect, and others using keywords related to the discussion of lipase, obesity, inhibition and bioactive compounds

  • Many studies have proven that the production of secondary metabolite compounds in medicinal plants can be increased in the presence of fermentation

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Summary

Introduction

Obesity is a condition of imbalance between height and weight due to excessive body fat tissue (Listiyana, Mardiana, & Prameswari, 2013). The rapid increase in the prevalence of obesity in the last 30 years shows the contribution of environmental factors (Comuzzie et al, 2012). This abnormal condition results in health problems in various diseases, such as type 2 diabetes mellitus, hyperlipidemia, atherosclerosis, cancer, and metabolic syndrome (Kim et al, 2019). The production of secondary metabolite compounds in medicinal plants can be increased in the presence of fermentation. Hasil: Salah satu cara pengendalian obesitas adalah dengan pengaturan pola diet dan konsumsi inhibitor lipase. Produksi senyawa metabolit sekunder pada tanaman obat dapat ditingkatkan dengan adanya fermentasi.

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