Abstract
ABSTRACT Groups of starved rats of both sexes were treated with three daily injections of either oestradiol benzoate (OB) alone or in combination with testosterone propionate (TP). The effect of these hormones on the concentration of the plasma unesterified fatty acids (UFA) was studied by withdrawing blood daily from the heart. For control conditions, groups of rats were treated with either olive oil, the vehicle of the above hormones, or no injection at all. It was found that oestradiol benzoate, 5 mg per dose, caused a mean rise of plasma UFA up to 1376 ± 209 μeq/litre; 10 mg OB per dose elevated the mean plasma UFA concentration to 3492 ± 246 μeq/litre; and a combination of 5 mg OB + 10 mg TP per dose resulted in a mean plasma UFA concentration of 2379 ± 236 μeq/litre. It is concluded that oestrogens possess a fat mobilising property similar to and possibly stronger than that of androgens.
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