Fat Mass and Obesity Association gene Polymorphism in PCOS Iraqi Women

Qais Ahmed Ibraheem,Luma Hasan Alwan Al Obaidy,Manal Taha Al Obaidi,Gulboy Abdolmageed Nasir

doi:10.21123/bsj.2020.17.3(suppl.).1103

Qais Ahmed Ibraheem, Luma Hasan Alwan Al Obaidy + Show 2 more

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https://doi.org/10.21123/bsj.2020.17.3(suppl.).1103

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Abstract

Polycystic syndrome (PCOS) is a considerable infertility disorder in adolescents and adult women in reproductive age. Obesity is a vigorous risk factor related to POCS. This study aims to evaluate the association of obesity and PCOS by investigating several parameters including: anthropological, biochemical (lipid profile, fasting blood sugar, glucose tolerance test, and hormone levels (LH, FSH, LH/FSH ratio, Estradiol2 and Testosterone),and genetic parameters (Fat mass and Obesity associated gene (FTO) polymorphism at rs17817449) in 63 obese and non-obese PCOS women. The biochemical tests were investigated by colorimetric methods while FTO gene polymorphism was detected by PCR–RFLP. Lipid profile, FBS, GTT, hormones (LH, LH/FSH ratio) in obese PCOS patients were significantly higher than non-obese non PCOS patients. It was found that the FTO variant TT risk genotype is a predisposing factor to obesity but not for PCOS. The study substantiated a possible familial risk factor for developing obesity among women in the same family.

Highlights

Polycystic ovary syndrome (PCOS) is a complex infertility disorder in adolescents (1) and adult women in the reproductive age (2)
This study aims to evaluate the association of obesity and PCOS by investigating several parameters including: anthropological, biochemical (lipid profile, fasting blood sugar, glucose tolerance test, and hormone levels (LH, FSH, LH/FSH ratio, Estradiol[2] and Testosterone),and genetic parameters (Fat mass and Obesity associated gene (FTO) polymorphism at rs17817449) in 63 obese and non-obese PCOS women
There were no significant differences in the age of women (26.35 ± 4.11, 23.67 ± 4.17, and 28.81± 4.49 and 26.82 ± 3.97) years, of the obese PCOS, non-obese PCOS, obese non-PCOS and non-obese non-PCOS groups respectively

Summary

Introduction

Polycystic ovary syndrome (PCOS) is a complex infertility disorder in adolescents (1) and adult women in the reproductive age (2). The potential genetic investigations focused on the expression ,mutations and polymorphism in metabolism related genes, action related genes and genes that encode for reproductive controlling hormones and their receptor(10). Structural chromosomal aberration such as X chromosome aberration leading to abnormal follicular behavior and deletion of the loge arm of chromosomes 2, 11, 16, 19 were reported in some PCOS cases (11, 12, 13, 14 and 15). It is not clear whether obesity leads to PCOS or vice versa. The cornerstone for both PCOS and obesity is insulin resistance that leads to excess levels of insulin and glucose uptake failure by adipose and muscle cells, increasing the risk of diabetes type II (16), dyslipidemia, decrease in high density lipoprotein cholesterol, hypertriglyceridemia and hypertension which are highly associated with cardiovascular diseases (17)

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