Fasting sugar, blood pressure, and uric acid are factors related to positive proteinuria and an impaired eGFR

Abstract

BackgroundThe aim of this study was to ascertain the relationships of blood pressure, fasting sugar level, triglyceride (TG) level, uric acid level, and body mass index (BMI) with proteinuria and the estimated glomerular filtration rate (eGFR) in a population from southern Taiwan. MethodsThe 20,900 subjects enrolled in this study had undergone a free adult health examination under the National Health Insurance scheme between September 2005 and June 2011. Factors such as blood pressure, blood sugar, TG, uric acid and BMI were examined in terms of their relationships with the eGFR (calculated according to the Taiwanese Modification of Diet in Renal Disease (Taiwanese-MDRD)) and proteinuria. The Chi-square test, Student's t-test or the Mann–Whitney U-test, and multivariate logistic regression analysis were employed. ResultsThe prevalence of chronic kidney disease (CKD) was 66.7%. Multivariate logistic analysis showed that fasting sugar (OR = 1.12 and 1.65), blood pressure (OR = 1.09 and 1.12), and triglyceride levels (OR = 1.40 and 1.38) were factors related to positive proteinuria and an impaired eGFR. ConclusionCKD is prevalent in the southern Taiwanese population aged over 40 years, and we believe that controlling related risk factors could be an important method by which to prevent progression of CKD.