Abstract
ObjectiveAlthough several epidemiological studies assessed the relationship between fasting plasma glucose (FPG) and serum uric acid (SUA) levels, the results were inconsistent. A cross-sectional study was conducted to investigate this relationship in Chinese individuals with normal glucose tolerance.Research design and methodsA total of 5,726 women and 5,457 men with normal glucose tolerance were enrolled in the study. All subjects underwent a 75-g oral glucose tolerance test. Generalized additive models and two-piecewise linear regression models were applied to assess the relationship.ResultsA U-shaped relationship between FPG and SUA was observed. After adjusting for potential confounders, the inflection points of FPG levels in the curves were 4.6 mmol/L in women and 4.7 mmol/L in men respectively. SUA levels decreased with increasing fasting plasma glucose concentrations before the inflection points (regression coefficient [β] = -36.4, P < 0.001 for women; β = -33.5, P < 0.001 for men), then SUA levels increased (β = 17.8, P < 0.001 for women; β = 13.9, P < 0.001 for men). Additionally, serum insulin levels were positively associated with FPG and SUA (P < 0.05).ConclusionsA U-shaped relationship between FPG and SUA levels existed in Chinese individuals with normal glucose tolerance. The association is partly mediated through serum insulin levels.
Highlights
Uric acid, the final oxidation product of purine metabolism in human beings, possesses both antioxidant and pro-oxidant properties [1]
serum uric acid (SUA) levels decreased with increasing fasting plasma glucose concentrations before the inflection points, SUA levels increased (β = 17.8, P < 0.001 for women; β = 13.9, P < 0.001 for men)
Serum insulin levels were positively associated with fasting plasma glucose (FPG) and SUA (P < 0.05)
Summary
The final oxidation product of purine metabolism in human beings, possesses both antioxidant and pro-oxidant properties [1]. The levels of serum uric acid (SUA) are determined by a balance of production, reabsorption and secretion [2]. Because of the evolutionary loss of hepatic uricase by mutational silencing, uric acid is present at higher levels in human blood than in other mammals [3]. Uric acid has proven emerging roles in various diseases such as gout, renal dysfunction, hypertension, hyperlipidemia, diabetes and obesity [4,5,6,7]. Hyperuricemia occurs as a result of the abnormal increased uric acid production and/or the impaired renal uric acid excretion [8]. Clarifying the association between plasma glucose and SUA levels in population with normal glucose tolerance benefits the screening and prevention of diabetes
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