Abstract
Introduction: Insulin resistance (IR) is an independent cardiovascular risk factor. Aim: The study aimed at comparing a potential novel marker, fasting insulin-lipid (FILIP) index, with homoeostatic model assessment of IR (HOMA-IR) and McAuley's index, in terms of IR quantitation and cardiovascular risk predictability. Methods: The study involved 70 individuals (35 females and 35 males) who were previously diagnosed with Type 2 diabetes mellitus. Ethical approval was obtained from the Institution's Ethical Review Committee. Fasting plasma insulin, fasting plasma glucose, plasma triglyceride (TG) and high-density lipoprotein-cholesterol (HDL-C) were determined with appropriate techniques. QRISK 3 was obtained from a validated calculator. FILIP index, HOMA-IR and McAuley's index were obtained from the recommended formulae. SPSS version 22 was used for data analysis. Pearson's correlation was used to compare the indices. Bland–Altman plots comparing FILIP index with HOMA-IR and McAuley's index were done. Receiver operating characteristic (ROC) curve analysis was done to determine the cardiovascular risk predictability of the indices. Results: The mean age was 53.34 ± 9.57 years. FILIP index significantly correlated with HOMA-IR (r = 0.514; P < 0.0001) and McAuley's index (r = −0.830; P < 0.0001). The Bland–Altman plots between FILIP index and HOMA-IR as well as between FILIP index and McAuley's index showed reasonably acceptable limits of difference. ROC curve analysis in determining cardiovascular risk predictability showed that FILIP index had the highest area under curve. Conclusion: FILIP index is a simple derivative of fasting insulin multiplied by TG-HDL-C ratio. As a surrogate marker of IR, FILIP index compared well with HOMA-IR and McAuley's index. In Type 2 diabetes mellitus, FILIP index is a better predictor of cardiovascular risk when compared with HOMA-IR and McAuley's index.
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