Fasting hyperglycaemia with oral glucose tolerance in acute Trypanosoma congolense infection of rats

Abstract

Intraperitoneal inoculation of rats with Trypanosoma congolense (Federe strain) produced a sustained parasitaemia from days 7 to 23 post-infection (pi). The fasting tail-blood glucose (FBG) concentrations in the infected animals increased ( p<0.05) from 3.8±0.2 mmol/l on day 0 pi to 4.6±0.2, 4.9±0.2 and 5.8±0.3 mmol/l on days 7, 10 and 17 pi and decreased ( p<0.05) to 3.1±0.8 and 2.9±0.7 mmol/l on days 20 and 23 pi, but the values in the uninfected controls varied between 3.8±0.3 mmol/l on day 0 pi and 3.9±0.2 mmol/l on day 23 pi. After oral glucose intake (1.0 g/kg) and determination of tail-blood glucose (BG) concentrations after 2 h, the percentage increase in BG from FBG was either comparable in infected and uninfected groups (days 7, 20, 23 pi) or lower ( p<0.05) in the infected group (days 10, 17), suggesting the same rate of tissue glucose delivery in both groups or a faster rate in the infected group. Therefore, oral glucose tolerance in the infected rat was not impaired, but there was initial fasting hyperglycaemia followed by fasting hypoglycaemia in the later stage.