Abstract
We retrospectively analyzed the occasional fasting BG concentration of 21 children and OGTT of 7 subjects who developed IDDM 60-8 months later. Approaching symptomatic diabetes the fasting BG levels (72-115 mg/dl) progressively increased with a r-value of 0.68 ( p<0.005) and the peak insulin release at OGTT (40-26 uU/ml) declined in a similar linear manner (r=0.97; p<0.01). Abnormal BG elevations in response to OGTT have been noticed in all subjects at 60 min. (> 180 mg/dl)and in 3 of them also at 180 min (> 140 mg/dl); glycosuria appeared in 2 subjects. In spite of these abnormalities BG levels were not further controlled before the overt onset of IDDM. These retrospective data (rarely available in the PL of IDDM in children) confirm that the abrupt clinical onset of diabetes may be preceeded by a long period of abnormal BG levels and insulin secretory capacity. We suggest that monitoring of these parameters may constitute an effective and non-expensive measure to identify children at risk for IDDM and to admit them to immunological and genetic investigations.
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