Abstract
Fasting Apolipoprotein B48 (ApoB48) is reported to be a well surrogate marker for postprandial lipidemia and have been repeatedly associated with cardiovascular disease. However, whether ApoB48 is also a risk factor for ischemic stroke have not been reported. In this study, our object is to explore the relationship between fasting plasma ApoB48 levels and the large artery atherosclerotic (LAA) stroke.A 1:1 age-(±2), gender-matched case-control study was conducted. LAA patients and healthy controls admitted to our center were prospectively recruited. Clinical data were collected and enzyme-linked immunosorbent assay (ELISA) was used to measure the fasting plasma ApoB48 levels.A cohort of 234 LAA stroke patients and 234 controls were enrolled. Fasting plasma ApoB48 levels were significantly higher in LAA stroke patients than in controls (4.76(3.46) vs 4.00(2.4), P < 0.001). Conditional multivariable analyses indicated that fasting ApoB48 levels were associated with LAA stroke (odds ratio: 1.18; 95% confidence interval: 1.04–1.35; P = 0.014).Our study indicates that increased fasting plasma ApoB48 may be a risk factor for LAA stroke.
Highlights
Hypertriglyceridemia (HTG) is a common type of dyslipidemia, especially in China
When the plasma levels of Apolipoprotein B48 (ApoB48) were dichotomized at 5.29 μg/mL according to the ROC curve analysis, the patients in large artery atherosclerotic (LAA) stroke group had a significantly higher proportion of high ApoB48 levels (42.74% vs. 23.50%, p < 0.001), compared with controls
We demonstrated that, for the first time, fasting ApoB48 levels were higher in LAA stroke patients, and a higher ApoB48 level (ApoB48 > 5.29 μg/mL) was nearly two times more prevalent in LAA stroke patients (42.74%) than in controls (23.50%)
Summary
Hypertriglyceridemia (HTG) is a common type of dyslipidemia, especially in China. HTG could initiate and promote the atherosclerotic process, which could in turn accelerate cardiovascular disease[1]. Several studies have revealed that elevated fasting triglyceride level is a risk factor for ischemic stroke[2,3]. In contrast to the above inconsistence findings, nonfasting triglyceride levels were reported consistently to be a risk factor for ischemic stroke in the Copenhagen City Heart Study[6,7] and Women’s Health Study[8]. These results indicated that nonfasting or postprandial triglyceride levels may be a more suitable biomarker for ischemic stroke and atherosclerotic disease compared to fasting triglyceride levels. Our objective in this study was to explore the relationship between fasting plasma ApoB48 levels and the large artery atherosclerotic (LAA) stroke
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