Abstract
An improved GLC method was employed to study individual serum bile acids in 14 control subjects after a 12-hour fast followed by a standard fatty meal. Peripheral venous blood samples were obtained at 15-min intervals for up to 2 h in 7 subjects, and 4 h in 2 subjects. The fasting total bile acids, and cholic:chenodeozycholic acid ratio fell within a narrow range. The total bile acids and chenodeoxycholic acid increased significantly within 30 min of the meal, to reach peak values within 75-120 min. The extent of the increase was variable, and the range of values increased progressively after the meal.
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