Abstract
Skin serves as the first protective line and barrier of the body. Like many other organs, skin can be affected by several disorders in response to external factors such as pathogens, ultraviolet light, and pollution, as well as endogenous alterations related to aging and/or oxidative stress disturbance. Researchers have reported new insights into how skin cells are altered in response to caloric restriction diets in mammals. One of the most well-known caloric restriction diets is the Ramadan intermittent fasting, which is a radical change in the diet plan of practitioners for the period of one lunar month. Ramadan fasting represents the fourth of the five pillars of the Islamic creed. Even though infirm individuals are waived to take part in this religious duty, patients with various health problems, including those with different skin disorders, might choose to share this event with peers and family members. No standardized protocols or guidelines exist, however, to advise their physicians on the proper management of their patients’ condition during fasting. With an increasing Muslim population living in Western countries, this topic has started to draw substantial attention, not only of Middle-Eastern physicians, but also of clinicians in the West. For this purpose, we carried out a comprehensive overview on the topic. Our main findings are that: (1) there is a strong need for evidence-based suggestions and guidance. Literature on the impact of the Ramadan fasting, as well as of other kinds of fasting, on skin diseases is scarce and of poor quality, as well as the information available from the Internet; (2) patients willing to fast should be advised about the importance of taking proper treatments or consider alternative options including administration of trans-dermal/topical drugs, as they are permitted during daylight hours. Further, non-compliance has important, clinical and economic implications for an effective patient management.
Highlights
Data on the effects of Ramadan fasting on skin disorders, is less well known and no standardized guidelines exist for advising optimal management methods and options
The research group recorded a addition to down-regulation of the expression of 31 and 34 genes related to mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K) pathways, decrease of Ras-MAPK and PI3K-Akt pathways, in addition to down-regulation of the expression of respectively
The following knowledge gaps can be listed: (1) There is a strong need for evidence-based suggestions and guidelines
Summary
Skin disorders disordersare arecommonly commonlywidespread widespread skin conditions affecting children adults may induce severe disability [1,2,3].[2,3,4]. All skin combined represent the fourth leadingleading cause and may induce severe disability. Allconditions skin conditions combined represent the fourth of non-fatal disability worldwide, especially in resource-poor regions [4]. In 2013, disorders cause of non-fatal disability worldwide, especially in resource-poor regions [5]. 306 diseases and estimations are are likely to differ among countriesdepending dependingononthe thedifferent different healthcare healthcare systems systems and lifestyles likely to differ among countries lifestyles adopted adopted [5].
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