Faster Registration on International Donor Registries and Shorter Time to Allogeneic Hematopoietic Stem Cell Transplantation After Having Found a Donor Confers Better Outcome in Acute Leukemia Patients

Abstract

A patient has 30% chance to find an HLA identical sibling donor (SD) and 40% chance to find a suitable unrelated donor (UD), 40% of registered patients on international registries relapse or die before finding a donor. We evaluated the outcome in acute leukemia (AL) patients, whether they had an HLA identical SD, an UD or no donor (ND) after registration on France Greffe de Moelle (FGM) registry, either transplanted later or not. Secondary objectives were to evaluate the impact of intervals diagnosis-allo-HSCT, donor finding-allo-HSCT, registration-allo-HSCT, on OS and EFS.