Fast repair of oxidizing oh radical adduct of dGMP by hydroxycinnamic acid derivatives. A pulse radiolytic study

Abstract

Using the technique of pulse radiolysis, it has been demonstrated that the interaction of the oxidizing OH radical adduct of 2′-deoxyguanosine-5′-monophosphate (dGMP) with hydroxycinnamic acid derivatives proceeds via an electron transfer reaction. From buildup kinetics of radical species the rate constants of electron transfer from hydroxycinnamic acid derivatives to the oxidizing OH radical adduct of dGMP have been determined to be k ≈ (2–3) x 10 9 dm −3 mol −1 s −1. The yields for oxidizing OH radical adduct of dGMP are determined to be G ≈ 2.8.