Abstract
In this study, a facile method based on molecularly imprinted polymers (MIPs) combined with internal extractive electrospray ionization tandem mass spectrometry (iEESI-MS/MS) was developed for the quantitative analysis of fluoroquinolones (FQs) in environmental water samples. FQ molecules in water samples were captured by the MIPs, which was retained on a 0.22 μm syringe filter. Then, an electrospray solution selected as the elution solution was employed to extract the FQs from the MIPs, getting an eluate of FQs for mass spectrometric interrogation. Under the optimized experimental conditions, low limits of detection (LODs, 0.015–0.026 μg L−1), with relative standard deviations (RSDs) less than 8.81% (n = 6) were obtained. The present method also provides good recoveries (91.14–103.60%) with acceptable precision (RSDs < 6.18%) and have no serious matrix effects for environmental water samples. The experimental results demonstrated that MIPs-iEESI-MS/MS has advantages including easy use, high speed (less than 3 min per sample) and high sensitivity for the analysis of FQs in environmental water samples, showing potential application in environmental science and water safety control.
Highlights
Fluoroquinolones (FQs) have been widely used in the treatment of bacterial infections.[1,2,3,4] some of the FQs cannot be absorbed completely, and are excreted through urine and excrement.[5]
The results demonstrated that molecularly imprinted polymers (MIPs)-Internal extractive electrospray ionization (iEESI)-MS/MS has advantages including easy use, high speed, high sensitivity for the analysis of FQs in environmental water, which has potential application in environmental science and water safety control
The MIPs-iEESI-MS/MS Collision induced dissociation (CID) experiments were performed by using a spiked blank water sample at the FQs concentration of 10 mg LÀ1
Summary
Fluoroquinolones (FQs) have been widely used in the treatment of bacterial infections.[1,2,3,4] some of the FQs cannot be absorbed completely, and are excreted through urine and excrement.[5]. E-mail: liangdp@jlu.edu.cn dSchool of Pharmaceutical Sciences, Peking University, Beijing 100191, China photodiode array (HPLC-PDA),[18] and enzyme immunoassays.[19,20] laborious sample pretreatments (e.g., centrifugation and chemical pre-extraction, etc.) and large volumes of organic solvents are usually required in the analysis of complex environmental water samples. A novel and facile method, termed MIPs extraction coupled with online iEESI-MS/MS elution and analysis (MIPs-iEESI-MS/MS) was designed and developed for the fast quanti cation of FQs in environmental water samples. FQs in water samples were selectivity captured by the MIPs material, held on a syringe lter and directly online eluted by the electrospray solution for mass spectrometric analysis. The results demonstrated that MIPs-iEESI-MS/MS has advantages including easy use, high speed, high sensitivity for the analysis of FQs in environmental water, which has potential application in environmental science and water safety control
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