Fast neutron irradiation of metastatic cervical adenopathy: The results of a randomized RTOG study

Abstract

Between 1977 and 1982, 199 evaluable patients with measurable cervical adenopathy were entered on a prospective, randomized RTOG study evaluating the use of fast neutrons in treatment of advanced, inoperable squamous cell carcinomas of the head and neck region. One hundred-eleven patients were randomized to receive mixed beam radiation therapy, and 88 were randomized to the photon control treatment. The complete response rates were 86% for mixed beam vs 75% for photons for Stage N, nodes, 62% for mixed beam vs 48% for photons for Stage N2 nodes, and 63 % for mixed beam vs 53 % for photons for N, nodes. The percents of patients remaining free of their adenopathy for two years were 78 % for mixed beam vs 55 % for photons for Stage N, nodes, 39 % for both mixed beam and photons for N2 nodes and 24 % for mixed beam vs 13 % for photons for N, nodes. The median disease-free status was 20.3 months for mixed beam treated patients and 6.4 months for photon-treated patients. Patients who had clearance of cervical adenopathy survived significantly longer than those who did not.