Abstract
Earlier the probability for the occurrence of quasisinusoidal oscillations in the mammal's brain redox-state potential ( E) (4–20 osc/min) recorded by an implanted platinum electrode has been shown to rise during high levels of behavior arousal [T.B. Shvets-Teneta-Gurii, K.Ju. Sarkisova, Change in oxidation–reduction potential of cerebral structures in the rat during paradoxical sleep, Translated from Dokl. Akad. Nauk SSSR 309 (1989) 1256–1259, Plenum, 1990; T.B. Shvets-Teneta-Gurii, V.N. Maz, O.B. Kovchegova, Rhythms of slow wave sleep and wakefulness in oscillations of the cerebral cortical redox potential, Bull. Exp. Biol. Med. 108 (1990) 1209–1211; T.B. Shvets-Teneta-Gurii, The rabbit's brain cortex redox-state potential in the course of hypnosis (immobilization stress), Dokl. USSR Acad. Nauk. 315 (1990) 1014–1017]. We supposed these oscillations to be generated by oscillations of the redox balance in glycolytic paths developing during a sharp increase in glycolysis rate similar to those described for populations of microorganism [A. Betz, B. Chance, Influence of inhibitors and temperature on the oscillations of reduced pyridine nucleotide in yeast cells, Arch. Biochem. Biophys. 109 (1965) 579–586]. To test the supposition, modelling experiments were done in which the classical method was used to increase glycolysis rate and to make glycolytic oscillations in the brain of a behaving rat by inhibition of the tissue respiration by KCN. It has been found that KCN injection (5–7 mg/kg, intraperitoneally (i/p), rats) induced within 10–20 min a significant decrease (for 15–150 mV) of the local brain E, and a chain of damped quasisinusoidal oscillations (frequency 4–12 osc/min, amplitude 0.5–10 mV) could occur in the local brain E for 3–15 min after KCN injection. These data suggest that the glycolytic oscillations could be one of the sources of the brain-event-related E oscillations monitored by the implanted platinum electrode.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
