Abstract
Accelerated drug release has been achieved by means of the fast rotation of magnetic gel beads. The magnetic gel bead consists of sodium alginate crosslinked by calcium chlorides, which contains barium ferrite of ferrimagnetic particles, and ketoprofen as a drug. The bead underwent rotational motion in response to rotational magnetic fields. In the case of bead without rotation, the amount of drug release into a phosphate buffer solution obeyed non-Fickian diffusion. The spontaneous drug release reached a saturation value of 0.90 mg at 25 minutes, which corresponds to 92% of the perfect release. The drug release was accelerated with increasing the rotation speed. The shortest time achieving the perfect release was approximately 3 minutes, which corresponds to 1/8 of the case without rotation. Simultaneous with the fast release, the bead collapsed probably due to the strong water flow surrounding the bead. The beads with high elasticity were hard to collapse and the fast release was not observed. Hence, the fast release of ketoprofen is triggered by the collapse of beads. Photographs of the collapse of beads, time profiles of the drug release, and a pulsatile release modulated by magnetic fields were presented.
Highlights
Many systems of drug release have been fabricated using polymer gel
Drug delivery system controlled by magnetic fields has been constructed by means of the fast rotation of magnetic gel beads
The magnetic gel bead consists of sodium alginate crosslinked by calcium chlorides, which contains barium ferrite of ferrimagnetic particles, and ketoprofen as a drug
Summary
Many systems of drug release have been fabricated using polymer gel. Polymer gels synthesized with the stimuli-responsive polymers undergo a volume phase transition in response to stimuli such as temperature, solvent, or pH. When the gel achieved the volume phase transition, additional pressures are generated on the gel. Various stimuli-responsive gels responding to temperature, pH, electric field, chemicals, and UV light have been employed to fabricate the novel drug delivery system. We attempted to construct the new system of drug delivery using magnetic gels responding to magnetic fields. It has been reported that the magnetic gel undergoes a variety of motion under magnetic fields. We found that the magnetic gel consisting of sodium alginate and barium ferrite particles demonstrates a rotational motion in response to rotational magnetic fields [14, 15]. The release behavior is briefly reported and the mechanism of the fast release is discussed
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