Abstract
HThe current work was planned to optimize promethazine theoclate fast-dissolving tablets using Box Behnken design. The effect of three independent factors, the concentration of camphor (sublimating agent), sodium starch glycolate (superdisintegrant) and β-cyclodextrin (solubility enhancer) on two responses, disintegration time and percent drug release was studied. A total of 27 formulations were prepared and tested for various precompression and postcompression parameters. The correlation between factors and responses was established by plotting contour plots. The independent variables, the concentration of camphor and sodium starch glycolate, have a significant influence on response disintegration time, whereas the factor, concentration of β-cyclodextrin, has an effect on the response and percent drug release.
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