Abstract
As precision of dosing and patient compliance become an important prerequisite for a long-term treatment of Tourette’s syndrome there is a need to develop formulation for this drug, which overcomes problems such as difficulty in swallowing, inconvenience in administration while travelling and patient’s acceptability. The present work was undertaken with a view to develop a fast dissolving tablets of Pimozide using Kyron T-314 as super-disintegrant along with Avicel PH 102 as diluent by response surface method using direct compression. Drug-excipient compatibility studies were confirmed by FTIR Spectroscopy. The tablets were evaluated for hardness, friability, weight variation, wetting time, disintegration time and uniformity of content and invitro dissolution. Based on evaluating parameters, formulation prepared by using 4.5% Kyron T-314 with 11.5% Avicel PH-102 was selected as optimized formulation and Formulation (F3) had disintegration time of 7.63±0.25s. and percentage cumulative drug release of 81.60 after 10min. The formulations were further studied and confirmed for their stability. Hence it was concluded that direct compression using Kyron T-314 superdisintegrant and Avicel PH 102 was simple and economic technique which can be used for formulation of fast dissolving tablets of Pimozide. Key word: Pimozide, Tourette’s syndrome, fast dissolving tablets, Kyron T 314, direct compression
Highlights
Across a wide variety of disease states, recent advances in drug delivery technologies have led to the development of innovative delivery systems designed to improve therapeutic outcome
Emerging delivery platforms for improved convenience and adherence with psychiatric medications is achieved with fast dissolving tablets (FDTs) which are ahead among the novel oral drug-delivery systems especially in pediatric and geriatric population with Dysphagia (Kane et al, 2003)
All the ingredients (Pimozide, mannitol, Avicel pH 102), except Acry flow L and Talc were passed through 60 mesh size separately and mixed
Summary
Across a wide variety of disease states, recent advances in drug delivery technologies have led to the development of innovative delivery systems designed to improve therapeutic outcome. Emerging delivery platforms for improved convenience and adherence with psychiatric medications is achieved with fast dissolving tablets (FDTs) which are ahead among the novel oral drug-delivery systems especially in pediatric and geriatric population with Dysphagia (Kane et al, 2003). Tics tend to be most severe in child and adolescent sufferers, so their presence has the potential to impact a period of life that is both critical for learning and is often associated with the experience of greater social tension and self-consciousness than adulthood. Pimozide is an orally active antipsychotic agent of the diphenyl-butylpiperidine series indicated for the suppression of motor and phonic tics in patients with Tourette's syndrome who have failed to respond satisfactorily to the standard treatment (Clare et al, 2011). Pimozide has an elimination half-life of 55h and undergoes hepatic metabolism and has about 40-50% bioavailability (Fog, 1980; Logan et al, 1982)
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