Abstract
In the present work, fast dissolving tablets of fexofenadine HCl were prepared by effervescent method with a view to enhance patient compliance. Three super-disintegrants viz., crospovidone, croscarmellose sodium and sodium starch glycolate along with sodium bicarbonate and anhydrous citric acid in different ratios were used and directly compressible mannitol (Pearlitol SD 200) to enhance mouth feel. The prepared batches of tablets were evaluated for hardness, friability, drug content uniformity and in vitro dispersion time. Based on the in vitro dispersion time (approximately 20 s), three formulations were tested for in vitro drug release pattern in pH 6.8 phosphate buffer, short-term stability at 40°/75% RH for 3 mo and drug-excipient interaction (IR spectroscopy). Among the three promising formulations, the formulation ECP3 containing 8% w/w of crospovidone and mixture of 24% w/w sodium bicarbonate 18% w/w of anhydrous citric acid emerged as the best (t50% 4 min) based on the in vitro drug release characteristics compared to conventional commercial tablet formulation (t50% 15 min). Short-term stability studies on the formulations indicated that there are no significant changes in drug content and in vitro dispersion time (P<0.05).
Highlights
Erwinia of extracts of C. trifoliata has been evaluated in vitro against gram positive and negative bacteria (Table 1) that are known to cause infections in humans and plants
Both the extracts showed significant inhibitory effect against Staphylococcus aureus, Bacillus subtilis, Enterobacter aerogenes and Escherichia coli at both concentrations (200 μg/ml and 800 μg/ml) they did not show any activity against Erwinia and Acinetobacter
Short-term stability studies on the formulations indicated that there are no significant changes in drug content and in vitro dispersion time (P
Summary
Erwinia of extracts of C. trifoliata has been evaluated in vitro against gram positive and negative bacteria (Table 1) that are known to cause infections in humans and plants. Both the extracts showed significant inhibitory effect against Staphylococcus aureus, Bacillus subtilis, Enterobacter aerogenes and Escherichia coli at both concentrations (200 μg/ml and 800 μg/ml) they did not show any activity against Erwinia and Acinetobacter. The aqueous and alcoholic extracts of C. trifoliata leaf possess significant inhibitory effect against the tested pathogens. The results obtained were comparable with those of standard drug ciprofloxacin. Both the extracts did not show any inhibitory effect on plant pathogens. The results of the study support the folklore claim of this plant
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
