Abstract
Anxiety appears among the most frequent psychiatric disorders. During recent years, a growing incidence of anxiety disorders can be attributed, at least in part, to the modification of our eating habits. To treat anxiety disorders, clinicians use benzodiazepines, which unfortunately display many side effects. Herein, the anxiolytic-like properties of two natural products (αS1–casein hydrolysate and Gabolysat®) were investigated in rats and compared to the efficacy of benzodiazepine (diazepam). Thus, the conditioned defensive burying test was performed after a unique oral dose of 15 mg/kg, at two time-points (60 min and then 30 min post oral gavage) to show potential fast-onset of anxiolytic effect. Both natural products proved to be as efficient as diazepam to reduce the time rats spent burying the probe (anxiety level). Additionally, when investigated as early as 30 min post oral gavage, Gabolysat® also revealed a fast-anxiolytic activity. To date, identification of bioactive peptide, as well as how they interact with the gut–brain axis to sustain such anxiolytic effect, still remains poorly understood. Regardless, this observational investigation argues for the consideration of natural compounds in care pathway.
Highlights
Anxiety disorders are among the most prevalent and disabling psychiatric disorders worldwide [1]
Diazepam is a well-known and frequently prescribed benzodiazepine, which already experimentally demonstrated its anxiolytic activity in the conditioned burying test
Our results confirm the efficacy of αS1–casein hydrolysate to dampen anxiety level but they demonstrate, for the first time, the efficacity of Gabolysat® to do so
Summary
Anxiety disorders are among the most prevalent and disabling psychiatric disorders worldwide [1]. On the market anxiolytic drugs are mostly benzodiazepine or benzodiazepine-like agents, which target the GABAergic system. Their use is not harmless and requires caution and vigilance. Risk-taking behavior have been observed under benzodiazepines prescription [6,7], together with impaired cognition, mobility and driving skills, as well as increased fall risk [8]. If their consumption lasts for a long period (usually considered as 3 months), GABAergic medications might create a tolerance and dependence [5]. Remote adverse effects have more recently been suspected, notably with an increased risk, to develop an Alzheimer’s disease [9]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
