Abstract
Activation of Aδ or Aδ plus C sensory afferents exhibits three kinds of synaptic response in the DCN neurons of the sacral spinal cord. Fast excitatory synaptic responses were mediated through the activation of AMPA and/or NMDA receptors by glutamate released from both AAδ and C sensory afferents. On the other hand, fast inhibitory responses were mediated by activation of GABAA or glycine receptors via GABAergic or glycinergic interneurons activated by sensory afferents. In addition, two kinds of slow excitatory synaptic response were elicited by repetitive stimulation of sensory afferents: one was mediated via NMDA receptor by activation of Aδ afferents; and the other was mediated by activation of NK1 receptors by substance P released apparently from C fiber sensory afferents. Thus, DCN neurons integrate direct excitatory and indirect excitatory and inhibitory fast inputs and modulate these fast inputs by slow excitatory responses.
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