Abstract

Salbutamol is an important drug that opens the medium and large air spaces in the lungs. In this study, CoFe3O4, CoFe3O4/MWCNT, and CoFe3O4/TiO2/MWCNT modified electrode structures are prepared separately to determine the effect of each modification agent on salbutamol responses. The prepared electrodes are firstly structurally characterized by the FT-IR technique. The surface morphology and structure of electrodes are then analyzed by SEM, and AFM techniques. EDX analyses were performed to clarify this structural change on the electrode surface. The salbutamol activity of the modified electrodes is determined by DPV in 0.1 M PBS. The modified electrode shows a linear response in the concentration range of 2-18 µM salbutamol, and an R2 value of 0.9587 is achieved. LOD and LOQ of the modified electrode are determined as 1.39 µM and 22.87 µM, respectively. Considering the reproducibility of the experimental results, non-interference of the interfering species, and the measurement range, it is determined that it can be successfully used to figure out the concentration of salbutamol in physiological fluids and commercial form.

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