Abstract
Pellets composed chiefly of inexpensive starches allow modulation of the rate of release of the poorly soluble drug triamcinolone acetonide in media of pH 1.2–6.8. Wheat- or maize-starch-based pellets with 20% of white dextrin release the drug in vitro almost completely within 20 min, while maize-starch-based pellets with 5–35% of waxy maize starch sustain gradual release over periods of 9–12 hr or longer when prepared using appropriate amounts of granulation fluid.
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