Fas/FasL and Apoptosis/Non-apoptosis

Abstract

The interaction of Fas and Fas ligand (FasL) is an important player in regulating apoptosis while Fas/FasL is also found to be involved into non-apoptosis regulation, which made it more attractive. To understand Fas/Fas ligand (FasL) and its function in the apoptosis and non-apoptosis regulation, a wide search was done by using internationally well-known databases and relevant papers were selected. Evidences supported that Fas/FasL signaling apoptotic pathway played a crucial role in the regulation of cell death and proliferation in various cell types. Numerous molecules were involved in the precise regulation of Fas/FasL mediated apoptosis through complicated signalling cascades. Nevertheless, the traditional apoptotic pathway, Fas/FasL signaling pathway, was also disclosed to function in non-apoptotic regulation in T cells via the interaction between T cell receptor and Fas/FasL and therefore Fas/FasL could be pivotal in maintaining the homeostasis of peripheral T cells and immune system.