Abstract
Meeting abstracts Memory CD8+ T cells (TMem) have the capacity to provide lifelong host protection against intracellular pathogens and cancer. Despite phenotypic and functional heterogeneity among TMem, the expression of Fas — a tumor necrosis family receptor (TNFR) superfamily member
Highlights
Memory CD8+ T cells (TMem) have the capacity to provide lifelong host protection against intracellular pathogens and cancer
Despite phenotypic and functional heterogeneity among TMem, the expression of Fas — a tumor necrosis family receptor (TNFR) superfamily member conventionally known as a death receptor — is held in common among all TMem subsets across multiple species
As Fas has been shown to mediate non-death signaling in other cell types, we set out to elucidate the role of Fas signaling in defined TMem subsets, including T stem cell memory (TSCM), T central memory (TCM), and T effector memory (TEM)
Summary
Memory CD8+ T cells (TMem) have the capacity to provide lifelong host protection against intracellular pathogens and cancer. Fas expression in memory CD8+ T cell subsets augments cellular differentiation and effector function From 30th Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2015) National Harbor, MD, USA.
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