Abstract
Chiliadenus lopadusanus Brullo is an Asteraceae plant species endemic to Lampedusa island, the largest island of the Pelage archipelago, Italy. The organic extract of its whole aerial parts, showing antibiotic activity against Staphylococcus aureus and Acinetobacter baumannii, wasfractionated employing bioguided purification procedures affording three main farnesane-type sesquiterpenoids. They were identified by spectroscopic methods (NMR and ESIMS data) as the (E)-3,7,11-trimethyldodeca-1,6,10-triene-3,9-diol, (E)-10-hydroxy-2,6,10-trimethyldodeca-2,6,11- trien-4-one and (E)-10-hydroxy-2,6,10-trimethyl-dodeca-6,11-dien-4-one, commonly named 9-hydroxynerolidol, 9-oxonerolidol, and chiliadenol B, respectively. These three sesquiterpenes, isolated for the first time from C. lopadusanus, were tested on methicillin-resistant S. aureus and A. baumannii showing antibacterial and antibiofilm activities. This plant could be used as a source to isolate secondary metabolites as potential new antibiotics.
Highlights
Antimicrobial resistance (AMR) is a phenomenon that seriously endangers the control of diseases around the world [1]
Compounds 1–3 were identified comparing their physics spectroscopic with data partially reported in the literature and in particular, for 9-hydroxynerolidol and 9-oxonerolidol (1 and 2)
With data reported by Stoessl et al [33] and for chiliadenol B (3) with those reported by Hegazy et al [34]
Summary
Antimicrobial resistance (AMR) is a phenomenon that seriously endangers the control of diseases around the world [1]. Microorganisms resistant to antimicrobials, including multidrug-resistant ones, are often the cause of healthcare-associated infections and infections of outpatients. They can be present in the normal bacterial flora of all healthy people, in companion animals and in the environment [2,3,4]. Antibiotic resistance is a phenomenon recognized all over the world as a priority in the health sector due to the important implications both from a clinical point of view (longer hospital stays, higher mortality) and from an economic point of view (rising costs) [6,7]
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