Abstract
The aim of this study was to evaluate reveal whether there is a significant relationship between cell proliferation and invasion-metastasis capacity in various mammary adenocarcinoma subtypes observed in dogs, by means of immunohistochemical markers such as PCNA and MMP-9. The material of this study was composed of tissue samples of mammary carcinomas taken from 6 Kangal and 4 Setter dogs with an average age of 8.4 years brought to our department between 2012-2020 years. Tissue samples from dogs were fixed in 10 % buffered formaldehyde solution. After routine tissue procedures, 5 μm thick sections were taken from paraffin blocks prepared for Hematoxylin and Eosin staining. Sections were examined under light microscope to determine the cancer patterns. Avidin-Biotin Peroxidase method was used as immunohistochemical method. 4 of 10 mammary carcinoma cases were classified as intraductal papillary carcinoma, 4 as carcinoma mixed, 1 as solid carcinoma and 1 as tubular carcinoma. We found the highest mean number of PCNA and MMP-9 positive cells in solid subtype. In conclusion, we thought that a positive relationship between cell proliferation and invasion and metastasis capacity under the solid subtype.
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