Abstract
Unlike fluorescence-based nanoscopy, far-field photostable optical nanoscopy (PHOTON) uses intrinsic size, shape, and surface-dependent localized-surface-plasmon-resonance (LSPR) spectra of single plasmonic nanoparticles (NPs) as multispectral (color) probes to achieve sub-diffraction optical imaging. PHOTON includes one standard dark-field optical microscope with a halogen-lamp illuminator (no need of laser excitation); single-molecule-nanoparticle-optical-biosensors (SMNOBS) with exceptionally high quantum-yield (QY) of Rayleigh scattering and photostability (non-photobleaching, non-photoblinking) as imaging probes; and Multispectral Imaging System (MSIS) for spectral isolation of individual SMNOBS with 1nm wavelength resolution. PHOTON offers superior sensing and imaging capabilities, and the SMNOBS provide unrivaled biocompatibility, photostability, and versatilities for quantitative and super-resolution imaging of single live cells with single molecular sensitivity.
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