Abstract
Far from being well understood: multiple protein phosphorylation events control cell differentiation in Bacillus subtilis at different levels
Highlights
CELL DIFFERENTIATION IN BACILLUS SUBTILIS In their endless struggle to survive in harsh and rapidly changing environments, many bacteria depend on their ability to live together as multicellular communities, known as biofilms
In the B. subtilis biofilm communities, different groups of cells fulfill distinct functions, which are important for the well-being of the whole community of clonal identical bacteria
NOVEL REGULATORY TYROSINE PHOSPHORYLATION ADDS EVEN MORE COMPLEXITY TO THE REGULATORY NETWORK FOR CELL DIFFERENTIATION Recent studies in B. subtilis suggest that tyrosine phosphorylation plays an important role in the regulation of biofilm formation and cell differentiation, in addition to the known mechanisms of transcriptional regulation and proteinprotein interactions
Summary
CELL DIFFERENTIATION IN BACILLUS SUBTILIS In their endless struggle to survive in harsh and rapidly changing environments, many bacteria depend on their ability to live together as multicellular communities, known as biofilms. Loss of the EpsB homolog PtkA did not affect extracellular polysaccharide production but instead drastically reduced sporulation in biofilm cells leading to a loss of the rough appearance of the outer region of the colonies (Kiley and Stanley-Wall, 2010; Gerwig et al, 2014).
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