Abstract
Abstract : Hemorrhagic shock is the leading cause of death in civilian and combat trauma. Even when the injured survive long enough to be transported to a medical facility, hemorrhage still remains the leading cause of preventable late death and complications. Effective hemorrhage control and better resuscitation strategies have the potential of saving lives. However, resuscitation can exacerbate cellular injury caused by hemorrhagic shock. Utilizing the funding provided by the ONR, we have clearly established that resuscitation fluids play a critical role in this injury pattern. Furthermore, we have demonstrated that these adverse effects can be avoided through simple modifications. We have also designed novel strategies for cellular protection. In parallel, advanced hemostatic battlefield dressings have been developed and validated. The goal of this research has been to improve the care of the critically injured, and a number of our findings have already been incorporated into new military doctrine (e.g. use of new hemostatic dressings, limited volume resuscitation), saving numerous lives.
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