Abstract
Progressive bone marrow failure and development of malignancies, particularly acute myeloid leukemia and solid tumors the most important features of Fan- coni’s Anemia (FA). This paper reports the case of a 16-year-old patient with FA who developped squa- mous cell carcinoma of the mandible, ten years after the bone marrow transplantation (BMT).
Highlights
Fanconi’s anemia is an autosomal recessive disorder characterized by constitutional aplastic anemia and congenital abnormalities [1]
This paper reports the case of a 16-year-old patient with Fanconi’s Anemia (FA) who developped squamous cell carcinoma of the mandible, ten years after the bone marrow transplantation (BMT)
We report the case of a 16-year-old boy with squamous cell carcinoma (SCC) of the mandible
Summary
Fanconi’s anemia is an autosomal recessive disorder characterized by constitutional aplastic anemia and congenital abnormalities [1]. The most important features of FA are progressive bone marrow failure and development of malignancies, acute myeloid leukemia and solid tumors [4,5]. Such patients are prone to the development of hematological malignancies and squamous cell carcinoma, especially of the head and neck [2,6,7]. The risk of squamous cell carcinoma development is especially high in the anogenital region as well as the head and neck region [1]. One case of SCC of the mandible in a patient with FA patient was reported in 1980 by Vaitiekaitis AS et al This is a report of a second case
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