Abstract
As part of a study of clinical and serological aberrations in relatives of probands with SLE, the results of tests for thyroid antibodies are presented. Familial aggregation of thyroid antibodies was less marked than of other autoantibodies in the present family material. Thyroglobulin and microsomal antibodies each occurred with higher frequency in relatives than in spouses, but a statistically significant difference was only present when thyroglobulin and microsomal antibodies were combined. There was a preponderance of thyroid diseases and antibodies in females, but no agedependent positivity. Thyroid diseases and antibodies were closely related in female relatives. A similar close relationship was also observed for thyroid diseases and antibodies in SLE probands. Thyroid diseases and antibodies were related in SLE probands and their female relatives. By contrast, the prevalence of thyroid disease and antibodies in spouses did not show any correlation to the presence or absence of diseases and antibodies in the SLE proband. Clinical thyroid disease occurred with equal frequency in female relatives of SLE probands without thyroid disease and in female spouses.
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