Abstract
Serum IgG concentrations, determined by the single radial diffusion method, in relatives (of 72 SLE probands) and their spouses were higher than in normal controls, but were unrelated to the clinical condition or residence of the family members. Generally, IgG concentrations above 1510 mg 100 ml (normal mean + 1 SD) and 1740 mg 100 ml (normal mean + 2 SD) occurred in females, higher age groups and second degree populations. However, an aggregation of increased IgG concentrations was found in the relatives compared with their spouses, most regularly in groups below 60 yr of age of first degree populations. The differences were mainly due to middle-aged males. The degree of significance of the differences between relatives and spouses was higher when both sexes, first and second degree populations and all age groups were combined and used in the calculations.
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