Abstract
ABSTRACTObjective: To evaluate the association between family history and the presence of dyslipidemia in children. Methods: A cross-sectional study with 257 children aged 4 to 7 years old from Viçosa, Minas Gerais, Southeast Brazil. Nutritional status and lipid profile (total cholesterol, cholesterol fractions, and triglyceride) assessments and an active search for a family history of dyslipidemia in parents were carried out. Pearson’s chi-square test was used to identify associations, and Student’s t-test was used to compare means. A Poisson regression analysis was performed to assess the independent association between family history and the presence of dyslipidemia in children. A significance level of 5% was adopted. Results: Children of parents with dyslipidemia had higher serum concentrations of total cholesterol and triglycerides. In a regression analysis after adjustments, the presence of dyslipidemia in the father or in the mother (OR: 2.43; 95%CI 1.12-5.27), as well as the presence of dyslipidemia in both the father and the mother (OR: 5.62; 95%CI 2.27-13.92) were associated with hypertriglyceridemia in children. Children of parents with dyslipidemia had a higher prevalence of elevated low-density lipoproteins (LDL-c) (OR: 1.52; 95%CI 1.18-1.97).Conclusions: An investigation of the family history of dyslipidemia should be made as part of the protocol to verify the presence of hypertriglyceridemia and dyslipidemia in children.
Highlights
Dyslipidemia occurs when lipoproteins are metabolically altered such that high serum concentrations of total cholesterol (TC), low density lipoproteins (LDL-c) and triglycerides (TG) are observed, as well as low serum concentrations of high density lipoproteins (HDL-c).[1]
The family history of dyslipidemia was associated with the presence of hypertriglyceridemia in children (Table 1)
We observed that the presence of dyslipidemia in both the father and the mother increased the prevalence of elevated LDL-c in children (PR: 1.52; 95%CI 1.18–1.97; p=0.001)
Summary
Dyslipidemia occurs when lipoproteins are metabolically altered such that high serum concentrations of total cholesterol (TC), low density lipoproteins (LDL-c) and triglycerides (TG) are observed, as well as low serum concentrations of high density lipoproteins (HDL-c).[1] Genetic factors, being overweight, sedentary behavior and poor nutrition may contribute to the onset of childhood dyslipidemia.[2,3]. History is one of the main factors that can detect dyslipidemia, as it is based on heredity, eating habits and the lifestyles shared by familes.[6] Parents are actively involved in the formation of children’s eating habits and physical activity routines since they are the ones that provide food and set examples of eating habits and meal times They pass on their preferences for specific foods and brands.[7]
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