Family History and BMI Correlate with Blood Pressure: A Cross-Section Study

Abstract

Hypertension is a general disease which is caused by complex polygenic inheritance, environment and multiple risk factors. The specific proportion of genes and the environment, however, was different in the previous published studies. The objective of this study is to identify the correlation between family history of hypertension (FH) and body mass index(BMI) with blood pressure based on cross section data. The correlation and interaction of FH and BMI on blood pressure is measured of 96646 patients with complete data which is selected from the database of screening in hypertension registry and follow-up management system by statistical analysis. 46.52% of patients with high blood pressure had FH, and 43.52% of patients with high blood pressure are overweight or obese. The average onset age of hypertension in cases without hypertension family history is 65.11 years old, and the average onset age in cases with hypertension family history is 60.17 years old. The average onset age of hypertension in cases in normal weight subjects is 64.01 years old, while the average age in overweight and obese subjects are respectively 61.55 and 61.11 years old. The independent effect of FH and BMI on SBP are OR=1.01 (95%CI:0.98～1.06) and OR=1.26 (95%CI:1.04～1.54) respectively, and the joint effect is OR=1.43 (95%CI:1.11～1.83); the independent effect on DBP are OR=1.75 (95%CI:1.66～1.85) and OR=1.99 (95%CI:1.89～2.09) respectively, and the joint effect is OR=2.37 (95%CI:2.25～2.50). The pure attributable proportion of interaction of FH and BMI on SBP is 37.21%, and that on DBP is 27.01%. FH and BMI have positive interaction with blood pressure. FH and BMI have positive correlation with blood pressure. Both of them (FH and BMI) can simultaneously increase the risk of hypertension, and lead to earlier age of onset.