Abstract
Background Single-nucleotide polymorphism within the gene encoding Vitamin D receptor (VDR) – a member of the nuclear receptor supergene family, is associated with several infectious diseases. The receptor belongs to the family of trans-acting transcriptional regulatory factors. Studies on VDR gene polymorphism reveals Fok I, Taq I, & Apa I restriction site variants to be significantly associated with many of the diseases compared to other SNPs within the gene. The study aims to determine the association of these polymorphisms with Hansen’s disease.
Highlights
Single-nucleotide polymorphism within the gene encoding Vitamin D receptor (VDR) – a member of the nuclear receptor supergene family, is associated with several infectious diseases
Studies on VDR gene polymorphism reveals Fok I, Taq I, & Apa I restriction site variants to be significantly associated with many of the diseases compared to other SNPs within the gene
The data indicates that a relationship exists between VDR polymorphic haplotype and the development of disease and the haplotypes C-T-C and T-T-C may perhaps render protection against Hansen’s disease
Summary
Familial study revealed the association of Vitamin D receptor gene haplotype with Hansen’s disease. From First International Science Symposium on HIV and Infectious Diseases (HIV SCIENCE 2012) Chennai, India. From First International Science Symposium on HIV and Infectious Diseases (HIV SCIENCE 2012) Chennai, India. 20-22 January 2012
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