Familial nephrotic syndrome: Does it matter?

Abstract

Abstract Steroid sensitive nephrotic syndrome (SSNS) is the most common form of nephrotic syndrome in childhood. Familial SSNS seems to be clinically homogeneous but reports on genetically informative SSNS families are lacking. Familial SSNS was found to be genetically distinct from familial steroid resistant nephrotic syndrome (SRNS). Several genes have been identified for SRNS. In general, genetic forms of nephrotic syndrome are resistant to common therapeutic approaches. But different cohort of steroid sensitive familial nephrotic syndrome were published. So precise clinical and genetic information on familial nephrotic syndrome are still lacking. Whether family history of nephrotic syndrome influences outcome is still in dilemma.