Abstract
Familial mediterranean fever (FMF) is a hereditary inflammatory disorder, which caused by mutations in MEFV gene located on short arm of Chromosome 16 p13.3.The majority of patients onset before the age of 10 years, which is characterized clinically by the episodes of inflammatory reaction and serositis, including fever, peritonitis, synovitis and pleurisy.AA-amyloidosis with kidney failure is the most important complication.The children patients were diagnosed mainly on clinical evaluation and the criteria developed by Yalinkaya.The ultimate goal of treatment in FMF is to obtain complete control of unprovoked attacks and minimise subclinical inflammation in between attacks.The only agent that decreases the frequency and severity of the episodes and the development of amyloidosis is colchicine, which should be started as soon as a clinical diagnosis is made, alternative biological treatments such as IL-1 receptor antagonist are indicated in patients with non-responders or resistant to colchicine. Key words: Familial mediterranean fever; MEFV gene; Alchi
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
