Familial Mediterranean Fever is associated with abnormal ventricular repolarization indices.

Elbis Ahbap,Abdulkadir Unsal,Tamer Sakaci,Cuneyt Akgol,Yener Koc,Seyfettin Gurbuz,Semi Ozturk,Zuhal Atan Ucar,Ekrem Kara,Feyza Bayraktar Caglayan,Arzu Ozdemir Kayalar,Taner Basturk,Mustafa Sevinc,Tuncay Sahutoglu

doi:10.4067/s0034-98872015001200009

Elbis Ahbap, Abdulkadir Unsal + Show 12 more

Open Access

https://doi.org/10.4067/s0034-98872015001200009

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Abstract

Cardiac arrhythmias can be a part of cardiovascular involvement in some rheumatic diseases, but data about familial Mediterranean fever (FMF) are conflicting. To search for abnormalities in ventricular repolarization indices in FMF patients. Seventy seven FMF patients and 30 age/gender comparable healthy controls were included. All patients were attack free and subjects with disease or drugs that are known to alter cardiac electrophysiology were excluded. Electrocardiographic data were obtained and analyzed. Twelve FMF patients had amyloidosis. QT and QTc intervals were within the normal ranges and similar between FMF patients and healthy controls. QT dispersion, peak to end interval of T wave (Tpe), Tpe/QT and Tpe/QTc ratios were significantly higher in FMF patients than in healthy controls. Patients with amyloidosis had significantly higher QT dispersion, Tpe, Tpe/QT and Tpe/QTc than their counterparts without FMF. Levels of proteinuria were moderately correlated with QT dispersion, Tpe, Tpe/QT and Tpe/QTc. FMF patients may have an increased risk for arrhythmias.

Highlights

Cardiac arrhythmias can be a part of cardiovascular involvement in some rheumatic diseases, but data about familial Mediterranean fever (FMF) are conflicting
All of the general characteristics were similar between FMF patients and the controls, except for mildly lower diastolic blood pressure and higher proteinuria, LV ejection fraction and LV mass index in the FMF group
Patients with amyloidosis had higher levels of proteinuria, LV mass index, erythrocyte sedimentation rate (ESR) and fibrinogen when compared to patients without amyloidosis (Table 3)

Summary

Introduction

Cardiac arrhythmias can be a part of cardiovascular involvement in some rheumatic diseases, but data about familial Mediterranean fever (FMF) are conflicting. Aim: To search for abnormalities in ventricular repolarization indices in FMF patients. Patients and Methods: Seventy seven FMF patients and 30 age/gender comparable healthy controls were included. QT and QTc intervals were within the normal ranges and similar between FMF patients and healthy controls. QT dispersion, peak to end interval of T wave (Tpe), Tpe/ QT and Tpe/QTc ratios were significantly higher in FMF patients than in healthy controls. Patients with amyloidosis had significantly higher QT dispersion, Tpe, Tpe/QT and Tpe/QTc than their counterparts without FMF. Levels of proteinuria were moderately correlated with QT dispersion, Tpe, Tpe/QT and Tpe/ QTc. Conclusions: FMF patients may have an increased risk for arrhythmias

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