Familial atrial fibrillation as a polygenic disease with structural cardiac abnormalities: assessment of genetic risk and possibilities for gene therapy

Abstract

The prevalence of familial atrial fibrillation (AF) in the general population and in the structure of AF is considered, and genetic predictors of AF and pathogenetic mechanisms of atrial remodeling are analyzed. The assessment of the genetic risk of AF occurrence, the prediction of its outcomes and the effectiveness of AF therapy, as well as the prospects for AF gene therapy are discussed.